Study of Eugenol and Salicylic Acid Interactions in Hybrid Molecule Encapsulated for Enhanced Antioxidant

Authors

  • Endah Setiani Astuti University of Brawijaya
  • Warsito Warsito University of Brawijaya
  • Arie Srihardyastutie University of Brawijaya

DOI:

https://doi.org/10.21776/ub.igtj.2023.012.02.02

Abstract

Drug development continues to be carried out so that drugs can work effectively. Creating a drug formula can be achieved by combining two or more synergistic drug compounds by hybridization, blending, or synthesis. This study reports findings of antioxidant activity using the good DPPH method from the synthesis of eugenol and salicylic acid using the encapsulation technique. The encapsulation technique uses chitosan as a coating material to protect the active ingredients, taking advantage of its unique functional characteristics, including the ability to form bonds with the crosslink agent sodium tripolyphosphate (Na-TPP) at a speed of 13,500 rpm with a pH of 4.2 to optimize the formulation. The encapsulation system produced the majority of particles measuring 241.0 ± 19.8 nm, with an encapsulation efficiency of 58.29 ± 0.40%. The encapsulation system produced the majority of particles measuring 241.0 ± 19.8 nm, with an encapsulation efficiency of 58.29 ± 0.40%. 

Keywords: antioxidant, blending, eugenyl, encapsulation, salicylate

Published

27-03-2024

Issue

Section

Articles